Identification of disease treatment mechanisms through the multiscale interactome

Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins; how drugs restore these functions, however, is often unknown. Here, the authors develop the multiscale interactome, a powerful approach to explain disease treatment.

Bibliographic Details
Main Authors: Camilo Ruiz, Marinka Zitnik, Jure Leskovec
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21770-8