Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells

Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells

Endoglin (Eng) is a co-receptor of the transforming growth factor β superfamily playing an important role in endothelial dysfunction. TRC105 (carotuximab) is a monoclonal antibody that blocks Eng and its downstream Smad signaling pathway. Here we have investigated for the first time the effects of T...

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Bibliographic Details
Main Authors: Katarina Tripska, Ivone Cristina Igreja Sá, Martina Vasinova, Matej Vicen, Radim Havelek, Samira Eissazadeh, Zuzana Svobodova, Barbora Vitverova, Charles Theuer, Carmelo Bernabeu, Petr Nachtigal
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Medicine
Subjects:
endoglin
TRC105
7-ketocholesterol
high glucose
endothelial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.845918/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.845918/full

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