LXR agonism for CNS diseases: promises and challenges
Abstract The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while liver X receptor (LXR) may regulate both processes due to its pivotal role in cholesterol metabolism and inflamma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-024-03056-0 |
| _version_ | 1797199244806848512 |
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| author | Ruiyi Zhang Emily Wuerch V. Wee Yong Mengzhou Xue |
| author_facet | Ruiyi Zhang Emily Wuerch V. Wee Yong Mengzhou Xue |
| author_sort | Ruiyi Zhang |
| collection | DOAJ |
| description | Abstract The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while liver X receptor (LXR) may regulate both processes due to its pivotal role in cholesterol metabolism and inflammatory response, and thus receives increasing attentions from neuroscientists and clinicians. Here, we summarize the signal transduction of LXR pathway, discuss the therapeutic potentials of LXR agonists based on preclinical data using different disease models, and analyze the dilemma and possible resolutions for clinical translation to encourage further investigations of LXR related therapies in CNS disorders. Graphical Abstract |
| first_indexed | 2024-04-24T07:12:41Z |
| format | Article |
| id | doaj.art-28fc2cc132ac453a943b5c9add5dc52a |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-04-24T07:12:41Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-28fc2cc132ac453a943b5c9add5dc52a2024-04-21T11:25:36ZengBMCJournal of Neuroinflammation1742-20942024-04-0121111310.1186/s12974-024-03056-0LXR agonism for CNS diseases: promises and challengesRuiyi Zhang0Emily Wuerch1V. Wee Yong2Mengzhou Xue3Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou UniversityHotchkiss Brain Institute and Department of Clinical Neurosciences, University of CalgaryHotchkiss Brain Institute and Department of Clinical Neurosciences, University of CalgaryDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou UniversityAbstract The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while liver X receptor (LXR) may regulate both processes due to its pivotal role in cholesterol metabolism and inflammatory response, and thus receives increasing attentions from neuroscientists and clinicians. Here, we summarize the signal transduction of LXR pathway, discuss the therapeutic potentials of LXR agonists based on preclinical data using different disease models, and analyze the dilemma and possible resolutions for clinical translation to encourage further investigations of LXR related therapies in CNS disorders. Graphical Abstracthttps://doi.org/10.1186/s12974-024-03056-0Liver X receptorNeurological diseasesNeuroinflammationCholesterol metabolismTissue regenerationClinical translation |
| spellingShingle | Ruiyi Zhang Emily Wuerch V. Wee Yong Mengzhou Xue LXR agonism for CNS diseases: promises and challenges Journal of Neuroinflammation Liver X receptor Neurological diseases Neuroinflammation Cholesterol metabolism Tissue regeneration Clinical translation |
| title | LXR agonism for CNS diseases: promises and challenges |
| title_full | LXR agonism for CNS diseases: promises and challenges |
| title_fullStr | LXR agonism for CNS diseases: promises and challenges |
| title_full_unstemmed | LXR agonism for CNS diseases: promises and challenges |
| title_short | LXR agonism for CNS diseases: promises and challenges |
| title_sort | lxr agonism for cns diseases promises and challenges |
| topic | Liver X receptor Neurological diseases Neuroinflammation Cholesterol metabolism Tissue regeneration Clinical translation |
| url | https://doi.org/10.1186/s12974-024-03056-0 |
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