Deficiency in Inactive Rhomboid Protein2 (iRhom2) Alleviates Alcoholic Liver Fibrosis by Suppressing Inflammation and Oxidative Stress

Deficiency in Inactive Rhomboid Protein2 (iRhom2) Alleviates Alcoholic Liver Fibrosis by Suppressing Inflammation and Oxidative Stress

Chronic alcohol exposure can lead to liver pathology relating to inflammation and oxidative stress, which are two of the major factors in the incidence of liver fibrosis and even liver cancer. The underlying molecular mechanisms regarding hepatic lesions associated with alcohol are not fully underst...

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Bibliographic Details
Main Authors: Yangwenshu Liu, Qin Kuang, Xianling Dai, Minxia Zhan, Li Zhou, Liancai Zhu, Bochu Wang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
alcoholic liver fibrosis
inflammation
iRhom2/TACE/NF-κB signaling pathway
oxidative stress
JNK
Online Access:https://www.mdpi.com/1422-0067/23/14/7701

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https://www.mdpi.com/1422-0067/23/14/7701

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