Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells
Back-propagating action potentials (bAP) and NMDA dendritic spikes have both been linked to long-term plasticity (LTP) induction, though it is unclear which factors are essential. Here, using electrophysiology and Ca2+imaging, the authors find NMDA spikes are a key initiator of LTP, and that bAP con...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13480 |