A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease.

A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease.

Inherited neurodegenerative disorders are debilitating diseases that occur across different species. We have performed clinical, pathological and genetic studies to characterize a novel canine neurodegenerative disease present in the Lagotto Romagnolo dog breed. Affected dogs suffer from progressive...

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Bibliographic Details
Main Authors: Kaisa Kyöstilä, Pernilla Syrjä, Vidhya Jagannathan, Gayathri Chandrasekar, Tarja S Jokinen, Eija H Seppälä, Doreen Becker, Michaela Drögemüller, Elisabeth Dietschi, Cord Drögemüller, Johann Lang, Frank Steffen, Cecilia Rohdin, Karin H Jäderlund, Anu K Lappalainen, Kerstin Hahn, Peter Wohlsein, Wolfgang Baumgärtner, Diana Henke, Anna Oevermann, Juha Kere, Hannes Lohi, Tosso Leeb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4398399?pdf=render

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http://europepmc.org/articles/PMC4398399?pdf=render

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