Imidazopyridine-Based Thiazole Derivatives as Potential Antidiabetic Agents: Synthesis, In Vitro Bioactivity, and In Silico Molecular Modeling Approach

Imidazopyridine-Based Thiazole Derivatives as Potential Antidiabetic Agents: Synthesis, In Vitro Bioactivity, and In Silico Molecular Modeling Approach

A new series of thiazole derivatives (<b>4a-p</b>) incorporating imidazopyridine moiety was synthesized and assessed for their in vitro potential α-glucosidase potency using acarbose as a reference drug. The obtained results suggested that compounds <b>4a</b> (docking score =...

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Bibliographic Details
Main Authors: Rafaqat Hussain, Wajid Rehman, Shoaib Khan, Aneela Maalik, Mohamed Hefnawy, Ashwag S. Alanazi, Yousaf Khan, Liaqat Rasheed
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceuticals
Subjects:
synthesis
thiazole
α-glucosidase
molecular docking
Online Access:https://www.mdpi.com/1424-8247/16/9/1288

Internet

https://www.mdpi.com/1424-8247/16/9/1288

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