Time-varying SMART design and data analysis methods for evaluating adaptive intervention effects

Abstract Background In a standard two-stage SMART design, the intermediate response to the first-stage intervention is measured at a fixed time point for all participants. Subsequently, responders and non-responders are re-randomized and the final outcome of interest is measured at the end of the st...

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Bibliographic Details
Main Authors: Tianjiao Dai, Sanjay Shete
Format: Article
Language:English
Published: BMC 2016-08-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12874-016-0202-7