TGF-β prevents phosphate-induced osteogenesis through inhibition of BMP and Wnt/β-catenin pathways.

TGF-β prevents phosphate-induced osteogenesis through inhibition of BMP and Wnt/β-catenin pathways.

BACKGROUND: Transforming growth factor-β (TGF-β) is a key cytokine during differentiation of mesenchymal stem cells (MSC) into vascular smooth muscle cells (VSMC). High phosphate induces a phenotypic transformation of vascular smooth muscle cells (VSMC) into osteogenic-like cells. This study was aim...

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Bibliographic Details
Main Authors: Fátima Guerrero, Carmen Herencia, Yolanda Almadén, Julio M Martínez-Moreno, Addy Montes de Oca, María Encarnación Rodriguez-Ortiz, Juan M Diaz-Tocados, Antonio Canalejo, Mónica Florio, Ignacio López, William G Richards, Mariano Rodriguez, Escolástico Aguilera-Tejero, Juan R Muñoz-Castañeda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3937350?pdf=render

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http://europepmc.org/articles/PMC3937350?pdf=render

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