TGF-β prevents phosphate-induced osteogenesis through inhibition of BMP and Wnt/β-catenin pathways.

TGF-β prevents phosphate-induced osteogenesis through inhibition of BMP and Wnt/β-catenin pathways.

<h4>Background</h4>Transforming growth factor-β (TGF-β) is a key cytokine during differentiation of mesenchymal stem cells (MSC) into vascular smooth muscle cells (VSMC). High phosphate induces a phenotypic transformation of vascular smooth muscle cells (VSMC) into osteogenic-like cells....

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Main Authors: Fátima Guerrero, Carmen Herencia, Yolanda Almadén, Julio M Martínez-Moreno, Addy Montes de Oca, María Encarnación Rodriguez-Ortiz, Juan M Diaz-Tocados, Antonio Canalejo, Mónica Florio, Ignacio López, William G Richards, Mariano Rodriguez, Escolástico Aguilera-Tejero, Juan R Muñoz-Castañeda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089179&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089179&type=printable

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