Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates

Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates

<p>Abstract</p> <p>Background</p> <p>Aggregation of soluble, monomeric β- amyloid (Aβ) to oligomeric and then insoluble fibrillar Aβ is a key pathogenic feature in development of Alzheimer’s disease (AD). Increasing evidence suggests that toxicity is linked to diffusibl...

Full description

Bibliographic Details
Main Authors: Sharoar Md, Thapa Arjun, Shahnawaz Mohammad, Ramasamy Vijay, Woo Eun-Rhan, Shin Song, Park Il-Seon
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Journal of Biomedical Science
Subjects:
Aβ
Kaempferol-3-O-rhamnoside
Oligomer
Aggregation
Cytotoxicity
Alzheimer’s disease
Online Access:http://www.jbiomedsci.com/content/19/1/104

Internet

http://www.jbiomedsci.com/content/19/1/104

Similar Items