Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells

Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells

Tumor escapes host immune responses by producing immunosuppressive cytokines, such as IL-10 and TGF-β, secreted into the tumor microenvironment. These cytokines play important roles in the suppression of dendritic cell (DC) function, leading to decreased immune responses of the effector CD4+ and CD8...

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Bibliographic Details
Main Authors: Chutamas Thepmalee, Aussara Panya, Mutita Junking, Thaweesak Chieochansin, Pa-thai Yenchitsomanus
Format: Article
Language:English
Published: Taylor & Francis Group 2018-06-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
cholangiocarcinoma (cca)
dendritic cell (dc)
immunosuppressive cytokines
il-10 receptor (il-10r)
tgf-β receptor (tgf-βr)
Online Access:http://dx.doi.org/10.1080/21645515.2018.1431598

Internet

http://dx.doi.org/10.1080/21645515.2018.1431598

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