Preclinical Evaluation of Dimethyl Itaconate Against Hepatocellular Carcinoma via Activation of the e/iNOS-Mediated NF-κB–Dependent Apoptotic Pathway

Preclinical Evaluation of Dimethyl Itaconate Against Hepatocellular Carcinoma via Activation of the e/iNOS-Mediated NF-κB–Dependent Apoptotic Pathway

Hepatocellular carcinoma (HCC) is one of the most common tumors affecting a large population worldwide, with the fifth and seventh greatest mortality rates among men and women, respectively, and the third prime cause of mortality among cancer victims. Dimethyl itaconate (DI) has been reported to be...

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Bibliographic Details
Main Authors: Anurag Kumar Gautam, Pranesh Kumar, Ritu Raj, Dinesh Kumar, Bolay Bhattacharya, P.S. Rajinikanth, Kumarappan Chidambaram, Tarun Mahata, Biswanath Maity, Sudipta Saha
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
dimethyl itaconate
hepatocellular carcinoma
NF-κB
mitochondrial apoptosis
1H-NMR–based metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.823285/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.823285/full

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