Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease

Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease

Antiviral responses are regulated by conjugation of ubiquitin (Ub) and interferon-stimulated gene 15 (ISG15) to proteins. Certain classes of viruses encode Ub- or ISG15-specific proteases belonging to the ovarian tumor (OTU) superfamily. Their activity is thought to suppress cellular immune response...

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Bibliographic Details
Main Authors: Florine E.M. Scholte, Marko Zivcec, John V. Dzimianski, Michelle K. Deaton, Jessica R. Spengler, Stephen R. Welch, Stuart T. Nichol, Scott D. Pegan, Christina F. Spiropoulou, Éric Bergeron
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
Crimean-Congo hemorrhagic fever
Bunyavirus
interferon
ubiquitin
innate immunity
ubiquitin specific protease
interferon stimulated gene-15
virus replication
reverse genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311476

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http://www.sciencedirect.com/science/article/pii/S2211124717311476

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