Notch1 Mediates Preconditioning Protection Induced by GPER in Normotensive and Hypertensive Female Rat Hearts

Notch1 Mediates Preconditioning Protection Induced by GPER in Normotensive and Hypertensive Female Rat Hearts

G protein-coupled estrogen receptor (GPER) is an estrogen receptor expressed in the cardiovascular system. G1, a selective GPER ligand, exerts cardiovascular effects through activation of the PI3K-Akt pathway and Notch signaling in normotensive animals. Here, we investigated whether the G1/GPER inte...

Full description

Bibliographic Details
Main Authors: Carmine Rocca, Saveria Femminò, Giorgio Aquila, Maria C. Granieri, Ernestina M. De Francesco, Teresa Pasqua, Damiano C. Rigiracciolo, Francesca Fortini, Maria C. Cerra, Marcello Maggiolini, Pasquale Pagliaro, Paola Rizzo, Tommaso Angelone, Claudia Penna
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
Subjects:
cardioprotection
preconditioning
H9c2
isolated rat hearts
reperfusion injury salvage kinases
PI3K/Akt
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00521/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00521/full

Similar Items