Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective

Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective

Abstract Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are cellular subdomains characterized by close apposition of mitochondria and ER membranes. They have been implicated...

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Bibliographic Details
Main Authors: Emma L. Wilson, Yizhou Yu, Nuno S. Leal, James A. Woodward, Nikolaos Patikas, Jordan L. Morris, Sarah F. Field, William Plumbly, Vincent Paupe, Suvagata R. Chowdhury, Robin Antrobus, Georgina E. Lindop, Yusuf M. Adia, Samantha H. Y. Loh, Julien Prudent, L. Miguel Martins, Emmanouil Metzakopian
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06568-y

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https://doi.org/10.1038/s41419-024-06568-y

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