A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine

A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine

The murine intestinal nematode Heligmosomoides polygyrus releases the H. polygyrus Alarmin Release Inhibitor (HpARI) - a protein which binds to IL-33 and to DNA, effectively tethering the cytokine in the nucleus of necrotic cells. Previous work showed that a non-natural truncation consisting of the...

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Bibliographic Details
Main Authors: Caroline Chauché, Francesco Vacca, Shin Li Chia, Josh Richards, William F. Gregory, Adefunke Ogunkanbi, Martin Wear, Henry J. McSorley
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
Heligmosomoides polygyrus
IL-33
allergy
cytokine
ILC2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01363/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01363/full

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