Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson’s Disease

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson’s Disease

Astrocytic dysfunction has been implicated in Parkinson’s disease (PD) pathogenesis. While the Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 signaling axis is known to play a role in PD-like neuropathology, the molecular mechanisms that govern this process remain poorly understoo...

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Bibliographic Details
Main Authors: Manikandan Samidurai, Prashant Tarale, Chelva Janarthanam, Crystal Gomez Estrada, Richard Gordon, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Anumantha G. Kanthasamy, Arthi Kanthasamy
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
TWEAK
STAT3
NLRC4
PKCδ
astrocyte
mitochondrial dysfunction
Online Access:https://www.mdpi.com/2073-4409/9/8/1831

Internet

https://www.mdpi.com/2073-4409/9/8/1831

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