FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation

FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation

Abstract Abnormal cardiac fibrosis is the main pathological change of post-myocardial infarction (MI) heart failure. Although the E3 ubiquitin ligase FBXL8 is a key regulator in the cell cycle, cell proliferation, and inflammation, its role in post-MI ventricular fibrosis and heart failure remains u...

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Bibliographic Details
Main Authors: Ya Li, Caojian Zuo, Xiaoyu Wu, Yu Ding, Yong Wei, Songwen Chen, Xiaofeng Lu, Juan Xu, Shaowen Liu, Genqing Zhou, Lidong Cai
Format: Article
Language:English
Published: Nature Publishing Group 2024-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06646-1

Internet

https://doi.org/10.1038/s41419-024-06646-1

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