Anti-VEGF therapy selects for clones resistant to glucose starvation in ovarian cancer xenografts

Anti-VEGF therapy selects for clones resistant to glucose starvation in ovarian cancer xenografts

Abstract Background Genetic and metabolic heterogeneity are well-known features of cancer and tumors can be viewed as an evolving mix of subclonal populations, subjected to selection driven by microenvironmental pressures or drug treatment. In previous studies, anti-VEGF therapy was found to elicit...

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Bibliographic Details
Main Authors: Daniele Boso, Martina Tognon, Matteo Curtarello, Sonia Minuzzo, Ilaria Piga, Valentina Brillo, Elisabetta Lazzarini, Jessica Carlet, Ludovica Marra, Chiara Trento, Andrea Rasola, Ionica Masgras, Leonardo Caporali, Fabio Del Ben, Giulia Brisotto, Matteo Turetta, Roberta Pastorelli, Laura Brunelli, Filippo Navaglia, Giovanni Esposito, Angela Grassi, Stefano Indraccolo
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ovarian cancer
Anti-angiogenic therapy
Glucose deprivation resistance
Mitochondria
Oxidative phosphorylation
Online Access:https://doi.org/10.1186/s13046-023-02779-x

Internet

https://doi.org/10.1186/s13046-023-02779-x

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