Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells

Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells

Abstract Accumulating evidence supports the existence of glioma stem cells (GSCs) and their critical role in the resistance to conventional treatments for glioblastoma multiforme (GBM). Differentiation therapy represents a promising alternative strategy against GBM by forcing GSCs to exit the cell c...

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Bibliographic Details
Main Authors: Zhijie Chen, Yingqian Zhong, Jiehong Chen, Shuxin Sun, Wenfeng Liu, Yu Han, Xincheng Liu, Cui Guo, Depei Li, Wanming Hu, Peiyu Zhang, Zhuopeng Chen, Zhongping Chen, Yonggao Mou, Guangmei Yan, Wenbo Zhu, Wei Yin, Ke Sai
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04957-9

Internet

https://doi.org/10.1038/s41419-022-04957-9

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