Allicin affects the pharmacokinetics of sulfadiazine and florfenicol by downregulating the expression of jejunum P-gp and BCRP in broilers

Allicin affects the pharmacokinetics of sulfadiazine and florfenicol by downregulating the expression of jejunum P-gp and BCRP in broilers

ABSTRACT: Allicin, one of the main bioactive compounds in garlic, is an excellent feed additive. It is unknown whether allicin affects the expression of P-gp and BCRP, 2 important ABC efflux transporters related to the pharmacokinetics of antimicrobials in chickens. In this study, by bidirectional t...

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Bibliographic Details
Main Authors: Xiaoming Wang, Yue Wang, Ci Fang, Qianmei Gong, Jinhu Huang, Yujuan Zhang, Liping Wang
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Poultry Science
Subjects:
allicin
P-gp
BCRP
inhibition
broilers
Online Access:http://www.sciencedirect.com/science/article/pii/S0032579122002395

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http://www.sciencedirect.com/science/article/pii/S0032579122002395

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