Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

Abstract MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a result, there is considerable interest in identifying chemical properties of metaboli...

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Bibliographic Details
Main Authors: Haihong Jin, Nicole A. Ladd, Andrew M. Peev, Gwendolyn M. Swarbrick, Meghan Cansler, Megan Null, Christopher T. Boughter, Curtis McMurtrey, Aaron Nilsen, Karen M. Dobos, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-26259-y

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https://doi.org/10.1038/s41598-022-26259-y

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