SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells

SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells

Type I interferons (type I-IFN) are critical for the host defense to viral infection, and at the same time, the dysregulation of type I-IFN responses leads to autoinflammation or autoimmunity. Recently, we reported that the decrease in monounsaturated fatty acid caused by the genetic deletion of Scd...

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Bibliographic Details
Main Authors: Toshio Kanno, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
CD4+ T cells
SCD2
fatty acid metabolism
IRF3
IFR9
RNA-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.904875/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.904875/full

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