Knock-Down of GPR88 in the Dorsal Striatum Alters the Response of Medium Spiny Neurons to the Loss of Dopamine Input and L-3-4-Dyhydroxyphenylalanine

Knock-Down of GPR88 in the Dorsal Striatum Alters the Response of Medium Spiny Neurons to the Loss of Dopamine Input and L-3-4-Dyhydroxyphenylalanine

The effects of L-3-4-dyhydroxyphenylalanine (L-DOPA) treatment for replacing the dopamine (DA) loss in Parkinson’s disease (PD) progressively wear off and are hindered by the development of dyskinesia, prompting the search for new treatments. The orphan G protein-coupled receptor 88 (Gpr88) represen...

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Bibliographic Details
Main Authors: Manuela Ingallinesi, Benjamin Galet, Jonathan Pegon, Nicole Faucon Biguet, Anh Do Thi, Mark J Millan, Clotilde Mannoury la Cour, Rolando Meloni
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
Gpr88
6-hydroxydopamine 6-OHDA
turning behavior
lentiviral vector
L-3-4-dyhydroxyphenylalanine–induced dyskinesia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01233/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01233/full

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