Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors

Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors

Show other versions (1)

K-Ras activating mutations are significantly associated with tumor progression and aggressive metastatic behavior in various human cancers including pancreatic cancer. So far, despite a large number of concerted efforts, targeting of mutant-type K-Ras has not been successful. In this regard, we aime...

Full description

Bibliographic Details
Main Authors: Mansour Poorebrahim, Mohammad Foad Abazari, Leila Moradi, Behzad Shahbazi, Reza Mahmoudi, Hourieh Kalhor, Hassan Askari, Ladan Teimoori-Toolabi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041843/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041843/?tool=EBI

Similar Items