piCRISPR: Physically informed deep learning models for CRISPR/Cas9 off-target cleavage prediction

piCRISPR: Physically informed deep learning models for CRISPR/Cas9 off-target cleavage prediction

CRISPR/Cas programmable nuclease systems have become ubiquitous in the field of gene editing. With progressing development, applications in in vivo therapeutic gene editing are increasingly within reach, yet limited by possible adverse side effects from unwanted edits. Recent years have thus seen co...

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Bibliographic Details
Main Authors: Florian Störtz, Jeffrey K. Mak, Peter Minary
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Artificial Intelligence in the Life Sciences
Subjects:
CRISPR
Cas9
Deep learning
Cleavage prediction
Nucleosome organisation
Online Access:http://www.sciencedirect.com/science/article/pii/S2667318523000193

Internet

http://www.sciencedirect.com/science/article/pii/S2667318523000193

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