Multiple functions of the ALT favorite helicase, BLM

Multiple functions of the ALT favorite helicase, BLM

Abstract Eukaryotic somatic cells undergo continuous telomere shortening because of end-replication problems. Approximately 10%~15% of human cancers rely on alternative lengthening of telomeres (ALT) to overcome telomere shortening. ALT cells are characterized by persistent telomere DNA replication...

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Bibliographic Details
Main Authors: Shun Chang, Jiang Tan, Ren Bao, Yanduo Zhang, Jinkai Tong, Tongxin Jia, Jing Liu, Juhua Dan, Shuting Jia
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell & Bioscience
Subjects:
BLM
Alternative lengthening of telomeres (ALT)
Telomere
Replication stress
Online Access:https://doi.org/10.1186/s13578-025-01372-3

Internet

https://doi.org/10.1186/s13578-025-01372-3

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