Interdependent Regulation of Polycystin Expression Influences Starvation-Induced Autophagy and Cell Death

Interdependent Regulation of Polycystin Expression Influences Starvation-Induced Autophagy and Cell Death

Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by deficiency of polycystin-1 (PC1) or polycystin-2 (PC2). Altered autophagy has recently been implicated in ADPKD progression, but its exact regulation by PC1 and PC2 remains unclear. We therefore investigated cell death and surv...

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Bibliographic Details
Main Authors: Jean-Paul Decuypere, Dorien Van Giel, Peter Janssens, Ke Dong, Stefan Somlo, Yiqiang Cai, Djalila Mekahli, Rudi Vennekens
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
ADPKD
autosomal dominant polycystic kidney disease
autophagy
cell death
nutrient stress
polycystins
Online Access:https://www.mdpi.com/1422-0067/22/24/13511

Internet

https://www.mdpi.com/1422-0067/22/24/13511

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