Generation and application of novel hES cell reporter lines for the differentiation and maturation of hPS cell-derived islet-like clusters

Generation and application of novel hES cell reporter lines for the differentiation and maturation of hPS cell-derived islet-like clusters

Abstract The significant advances in the differentiation of human pluripotent stem (hPS) cells into pancreatic endocrine cells, including functional β-cells, have been based on a detailed understanding of the underlying developmental mechanisms. However, the final differentiation steps, leading from...

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Bibliographic Details
Main Authors: Elisa Zanfrini, Manuj Bandral, Luka Jarc, Maria Alejandra Ramirez-Torres, Daniela Pezzolla, Vida Kufrin, Eva Rodriguez-Aznar, Ana Karen Mojica Avila, Christian Cohrs, Stephan Speier, Katrin Neumann, Anthony Gavalas
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Subjects:
Differentiation
Human pluripotent stem cells
Endocrine pancreas
Fluorescent reporter lines
Live imaging
Insulin-producing β-cells
Online Access:https://doi.org/10.1038/s41598-024-69645-4

Internet

https://doi.org/10.1038/s41598-024-69645-4

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