Presentation of an experimental method to induce in vitro ("organ chambers") respiratory acidosis and its effect on vascular reactivity

Presentation of an experimental method to induce in vitro ("organ chambers") respiratory acidosis and its effect on vascular reactivity

PURPOSE:To create in vitro a model to generate acidosis by CO2bubbling "organ chambers", which would be useful for researchers that aim to study the effects of acid-base disturbs on the endothelium-dependent vascular reactivity.METHODS:Eighteen male Wistar rats (230-280g) were housed, befo...

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Bibliographic Details
Main Authors: Tales Rubens de Nadai, Ana Paula Cassiano Silveira, Ariadne Santana e Neves Monteiro, Debora Ribeiro Campos, Marco Tulio Rezende de Carvalho, Agnes Afrodite Sumarelli Albuquerque, Andrea Carla Celotto, Paulo Roberto Barbosa Evora
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2014-11-01
Series:Acta Cirúrgica Brasileira
Subjects:
Acidosis, Respiratory
Endothelium
Nitric Oxide
Rats
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001100711&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001100711&tlng=en

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