Non-immunogenicity of overlapping gag peptides pulsed on autologous cells after vaccination of HIV infected individuals.

HIV Gag-specific CD4+ and CD8+ T-cell responses are important for HIV immune control. Pulsing overlapping Gag peptides on autologous lymphocytes (OPAL) has proven immunogenic and effective in reducing viral loads in multiple pigtail macaque studies, warranting clinical evaluation.We performed a phas...

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Main Authors: Henrik N Kløverpris, Akil Jackson, Amanda Handley, Peter Hayes, Jill Gilmour, Lynn Riddell, Fabian Chen, Mark Atkins, Marta Boffito, Bruce D Walker, Jim Ackland, Mark Sullivan, Philip Goulder
格式: Article
語言:English
出版: Public Library of Science (PLoS) 2013-01-01
叢編:PLoS ONE
在線閱讀:http://europepmc.org/articles/PMC3790804?pdf=render