Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery

Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery

Objectives: A prolonged cardiopulmonary bypass (CPB) time of over 180 min is linked to poorer outcomes and higher mortality in cardiac surgery. This study examines how glypican-1 shedding, matrix metallopeptidase 9 (MMP9), and the pro-inflammatory cytokine IL-1β may contribute to endothelial dysfunc...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Shiyi Li, Katherine V. Nordick, Iván Murrieta-Álvarez, Randall P. Kirby, Rishav Bhattacharya, Ismael Garcia, Camila Hochman-Mendez, Todd K. Rosengart, Kenneth K. Liao, Nandan K. Mondal
Materialtyp: Artikel
Språk:English
Publicerad: MDPI AG 2024-12-01
Serie:Biomedicines
Ämnen:
cardiopulmonary bypass
glypican-1
endothelial function
endothelial glycocalyx
cytokine
matrix metalloproteinase
Länkar:https://www.mdpi.com/2227-9059/13/1/33

Internet

https://www.mdpi.com/2227-9059/13/1/33

Liknande verk