Skeletal Muscle-Derived Exosomal miR-146a-5p Inhibits Adipogenesis by Mediating Muscle-Fat Axis and Targeting GDF5-PPARγ Signaling

Skeletal Muscle-Derived Exosomal miR-146a-5p Inhibits Adipogenesis by Mediating Muscle-Fat Axis and Targeting GDF5-PPARγ Signaling

Skeletal muscle-fat interaction is essential for maintaining organismal energy homeostasis and managing obesity by secreting cytokines and exosomes, but the role of the latter as a new mediator in inter-tissue communication remains unclear. Recently, we discovered that miR-146a-5p was mainly enriche...

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Bibliographic Details
Main Authors: Mengran Qin, Lipeng Xing, Jiahan Wu, Shulei Wen, Junyi Luo, Ting Chen, Yaotian Fan, Jiahao Zhu, Lekai Yang, Jie Liu, Jiali Xiong, Xingping Chen, Canjun Zhu, Songbo Wang, Lina Wang, Gang Shu, Qingyan Jiang, Yongliang Zhang, Jiajie Sun, Qianyun Xi
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
skeletal muscle
exosomes
miR-146a-5p
adipogenesis
GDF5
crosstalk
Online Access:https://www.mdpi.com/1422-0067/24/5/4561

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https://www.mdpi.com/1422-0067/24/5/4561

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