Complement Factor I Variants in Complement-Mediated Renal Diseases

Complement Factor I Variants in Complement-Mediated Renal Diseases

C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS) are two rare diseases caused by dysregulated activity of the alternative pathway of complement secondary to the presence of genetic and/or acquired factors. Complement factor I (FI) is a serine protease that downregulates compleme...

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Bibliographic Details
Main Authors: Yuzhou Zhang, Renee X. Goodfellow, Nicolo Ghiringhelli Borsa, Hannah C. Dunlop, Stephen A. Presti, Nicole C. Meyer, Dingwu Shao, Sarah M. Roberts, Michael B. Jones, Gabriella R. Pitcher, Amanda O. Taylor, Carla M. Nester, Richard J. H. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
complement
factor I
C3 glomerulopathy
atypical hemolytic uremic syndrome
C3 glomerulonephritis
dense deposit disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.866330/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.866330/full

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