Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate

Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate

Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP3 signalling pathway has been proposed as an atrial-specific target for AF therapy, and atrial IP3 signalling has been linked to the activation of calcium sensitive adenylyl cyclases...

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Bibliographic Details
Main Authors: Samuel J. Bose, Matthew J. Read, Emily Akerman, Rebecca A. Capel, Thamali Ayagama, Angela Russell, Derek A. Terrar, Manuela Zaccolo, Rebecca A. B. Burton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
inositol trisphosphate
adenylyl cyclase
cyclic AMP
cardiac atria
calcium signalling
pacemaking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.951897/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.951897/full

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