Lymphostatin, a virulence factor of attaching and effacing Escherichia coli, inhibits proliferation and cytokine responses of human T cells in a manner associated with cell cycle arrest but not apoptosis or necrosis

Lymphostatin, a virulence factor of attaching and effacing Escherichia coli, inhibits proliferation and cytokine responses of human T cells in a manner associated with cell cycle arrest but not apoptosis or necrosis

Lymphostatin is a virulence factor of enteropathogenic E. coli (EPEC) and non-O157 serogroup enterohaemorrhagic E. coli. Previous studies using whole-cell lysates of EPEC showed that lymphostatin inhibits the mitogen-activated proliferation of bulk human peripheral blood mononuclear cells (PBMCs) an...

Full description

Bibliographic Details
Main Authors: Nattaya Ruamsap, Donporn Riyapa, Sujintana Janesomboon, Joanne M. Stevens, Sathit Pichyangkul, Kovit Pattanapanyasat, Samandra T. Demons, Mark P. Stevens, Sunee Korbsrisate
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
lymphostatin
enteropathogenic Escherichia coli
inhibit T cell proliferation
cytokine suppression
G0/G1 cell cycle arrest
cyclin expression
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.941939/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.941939/full

Similar Items