Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated

Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated

Abstract We found ADAM8 enzymatic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs in ADAM8-inactivation mice that carry a mutation preventing self-activation of the enzyme. Surprisingly, elevated gene expression for inflammatory markers (Cxcl1, IL6) was...

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Bibliographic Details
Main Authors: Yejia Zhang, Zuozhen Tian, David Gerard, Lutian Yao, Frances S. Shofer, Gabriella Cs-Szabo, Ling Qin, Maurizio Pacifici, Motomi Enomoto-Iwamoto
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81495-y

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https://doi.org/10.1038/s41598-021-81495-y

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