Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination

Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination

Abstract While macrophage phagocytosis is an immune defense mechanism against invading cellular organisms, cancer cells expressing the CD47 ligand send forward signals to repel this engulfment. Here we report that the reverse signaling using CD47 as a receptor additionally enhances a pro-survival fu...

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Bibliographic Details
Main Authors: Chih-Wei Chou, Chia-Nung Hung, Cheryl Hsiang-Ling Chiu, Xi Tan, Meizhen Chen, Chien-Chin Chen, Moawiz Saeed, Che-Wei Hsu, Michael A. Liss, Chiou-Miin Wang, Zhao Lai, Nathaniel Alvarez, Pawel A. Osmulski, Maria E. Gaczynska, Li-Ling Lin, Veronica Ortega, Nameer B. Kirma, Kexin Xu, Zhijie Liu, Addanki P. Kumar, Josephine A. Taverna, Gopalrao V. N. Velagaleti, Chun-Liang Chen, Zhao Zhang, Tim Hui-Ming Huang
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42303-5

Internet

https://doi.org/10.1038/s41467-023-42303-5

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