Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS–Hook–FHIP complexes

Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS–Hook–FHIP complexes

In eukaryotic cells, intracellular components are organized by the microtubule motors cytoplasmic dynein-1 (dynein) and kinesins, which are linked to cargos via adaptor proteins. While ~40 kinesins transport cargo toward the plus end of microtubules, a single dynein moves cargo in the opposite direc...

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Bibliographic Details
Main Authors: Jenna R Christensen, Agnieszka A Kendrick, Joey B Truong, Adriana Aguilar-Maldonado, Vinit Adani, Monika Dzieciatkowska, Samara L Reck-Peterson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
dynein
dynactin
endosome
microtubule
Rab5
Rab1
Online Access:https://elifesciences.org/articles/74538

Internet

https://elifesciences.org/articles/74538

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