Subacute intranasal administration of tissue plasminogen activator increases functional recovery and axonal remodeling after stroke in rats

Subacute intranasal administration of tissue plasminogen activator increases functional recovery and axonal remodeling after stroke in rats

As a thrombolytic agent, application of recombinant tissue plasminogen activator (tPA) to ischemic stroke is limited by the narrow time window and side effects on brain edema and hemorrhage. This study examined whether tPA, administered by intranasal delivery directly targeting the brain and spinal...

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Bibliographic Details
Main Authors: Zhongwu Liu, Yi Li, Li Zhang, Hongqi Xin, Yisheng Cui, Leah R. Hanson, William H. Frey, II, Michael Chopp
Format: Article
Language:English
Published: Elsevier 2012-02-01
Series:Neurobiology of Disease
Subjects:
Functional recovery
Middle cerebral artery occlusion
Neuronal remodeling
Tissue plasminogen activator
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003731

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http://www.sciencedirect.com/science/article/pii/S0969996111003731

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