TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel
Numata et al examine whether the TRPM7 ion channel plays a role in the activation of volume-sensitive outwardly rectifying Cl− channels (VSOR) using human and chicken cell lines. By genetically-manipulating the expression of TRPM7 and performing electrophysiology, they demonstrate that TRPM7 is an e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02127-9 |
| _version_ | 1818842796842287104 |
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| author | Tomohiro Numata Kaori Sato-Numata Meredith C. Hermosura Yasuo Mori Yasunobu Okada |
| author_facet | Tomohiro Numata Kaori Sato-Numata Meredith C. Hermosura Yasuo Mori Yasunobu Okada |
| author_sort | Tomohiro Numata |
| collection | DOAJ |
| description | Numata et al examine whether the TRPM7 ion channel plays a role in the activation of volume-sensitive outwardly rectifying Cl− channels (VSOR) using human and chicken cell lines. By genetically-manipulating the expression of TRPM7 and performing electrophysiology, they demonstrate that TRPM7 is an essential regulator of VSOR activity. |
| first_indexed | 2024-12-19T04:47:40Z |
| format | Article |
| id | doaj.art-29513fd41dd64daea937648e873145ca |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T04:47:40Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-29513fd41dd64daea937648e873145ca2022-12-21T20:35:26ZengNature PortfolioCommunications Biology2399-36422021-05-014111410.1038/s42003-021-02127-9TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channelTomohiro Numata0Kaori Sato-Numata1Meredith C. Hermosura2Yasuo Mori3Yasunobu Okada4Department of Physiology, Graduate School of Medical Sciences, Fukuoka UniversityDepartment of Physiology, Graduate School of Medical Sciences, Fukuoka UniversityJohn A. Burns School of MedicineLaboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto UniversityNational Institute for Physiological SciencesNumata et al examine whether the TRPM7 ion channel plays a role in the activation of volume-sensitive outwardly rectifying Cl− channels (VSOR) using human and chicken cell lines. By genetically-manipulating the expression of TRPM7 and performing electrophysiology, they demonstrate that TRPM7 is an essential regulator of VSOR activity.https://doi.org/10.1038/s42003-021-02127-9 |
| spellingShingle | Tomohiro Numata Kaori Sato-Numata Meredith C. Hermosura Yasuo Mori Yasunobu Okada TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel Communications Biology |
| title | TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel |
| title_full | TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel |
| title_fullStr | TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel |
| title_full_unstemmed | TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel |
| title_short | TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel |
| title_sort | trpm7 is an essential regulator for volume sensitive outwardly rectifying anion channel |
| url | https://doi.org/10.1038/s42003-021-02127-9 |
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