The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling

The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling

Abstract In Huntington disease (HD), polyglutamine expansion in the huntingtin protein causes specific neuronal death. The consequences of the presence of mutant huntingtin in other tissues are less well understood. Here we propose that mutant huntingtin influences breast cancer progression. Indeed,...

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Bibliographic Details
Main Authors: Cristovão Moreira Sousa, John Russel McGuire, Morgane Sonia Thion, David Gentien, Pierre de la Grange, Sophie Tezenas du Montcel, Anne Vincent‐Salomon, Alexandra Durr, Sandrine Humbert
Format: Article
Language:English
Published: Springer Nature 2013-01-01
Series:EMBO Molecular Medicine
Subjects:
breast cancer
dynamin
huntingtin
migration
polyglutamine
Online Access:https://doi.org/10.1002/emmm.201201546

Internet

https://doi.org/10.1002/emmm.201201546

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