Constitutional and somatic methylation status of DMRH19 and KvDMR in Wilms tumor patients

Constitutional and somatic methylation status of DMRH19 and KvDMR in Wilms tumor patients

The most frequent epigenetic alterations in Wilms tumor (WT) occur at WT2, assigned to 11p15. WT2 consists of two domains: telomeric domain 1 (DMRH19) that contains the IGF2 gene and an imprinted maternally expressed transcript (H19) and centromeric domain 2 (KvDMR) that contains the genes KCNQ1, KC...

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Bibliographic Details
Main Authors: Leila C.A. Cardoso, Jair A. Tenorio Castaño, Hanna S. Pereira, Maria Angélica de F.D. Lima, Anna Cláudia E. dos Santos, Paulo S. de Faria, Sima Ferman, Héctor N. Seuánez, Julián B. Nevado, José Carlos Cabral de Almeida, Pablo Lapunzina, Fernando R. Vargas
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2012-01-01
Series:Genetics and Molecular Biology
Subjects:
epigenetic
histopathology
methylation
MS-MLPA
pyrosequencing
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500002

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000500002

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