Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

T follicular regulatory cells control the magnitude of the germinal centre response. Here the authors show that these cells display specificity to self as well as foreign antigens, and can arise from Foxp3-negative precursors at early stages of immunization in a PD-L1 dependent manner.

Bibliographic Details
Main Authors: Meryem Aloulou, Edward J. Carr, Mylène Gador, Alexandre Bignon, Roland S. Liblau, Nicolas Fazilleau, Michelle A. Linterman
Format: Article
Language:English
Published: Nature Portfolio 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10579