m6A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1

m6A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1

Androgen receptor splice variant 7 (AR-v7), a constitutively active transcription factor, plays a crucial role in the progression of castration-resistant prostate cancer (CRPC). Here, we found that the cleavage and polyadenylation specificity factor 1 (CPSF1) (the largest subunit of the multi-protei...

Full description

Bibliographic Details
Main Authors: Lei Xia, Qing Han, Xuehui Duan, Yinjie Zhu, Jiahua Pan, Baijun Dong, Weiliang Xia, Wei Xue, Jianjun Sha
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
SIAH1
CPSF1
androgen receptor
AR
AR-v7
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122000579

Internet

http://www.sciencedirect.com/science/article/pii/S2162253122000579

Similar Items