Mapping actionable pathways and mutations in brain tumours using targeted RNA next generation sequencing

Mapping actionable pathways and mutations in brain tumours using targeted RNA next generation sequencing

Abstract Many biology-based precision drugs are available that neutralize aberrant molecular pathways in cancer. Molecular heterogeneity and the lack of reliable companion diagnostic biomarkers for many drugs makes targeted treatment of cancer inaccurate for many individuals. Identifying actionable...

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Bibliographic Details
Main Authors: Krissie Lenting, Corina N. A. M. van den Heuvel, Anne van Ewijk, Duaa ElMelik, Remco de Boer, Elizabeth Tindall, Ge Wei, Benno Kusters, Maarten te Dorsthorst, Mark ter Laan, Martijn A. Huynen, William P. Leenders
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Acta Neuropathologica Communications
Subjects:
Glioma
Pathways
Diagnostics
Prognostics
Targeted RNA-sequencing
Single molecule molecular inversion probes
Online Access:http://link.springer.com/article/10.1186/s40478-019-0826-z

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http://link.springer.com/article/10.1186/s40478-019-0826-z

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