The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.

The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.

Fatty liver disease is an emerging public health problem without effective therapies, and chronic hepatic inflammation is a key pathologic mediator in its progression. Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have p...

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Bibliographic Details
Main Authors: Robert N Schuck, Weibin Zha, Matthew L Edin, Artiom Gruzdev, Kimberly C Vendrov, Tricia M Miller, Zhenghong Xu, Fred B Lih, Laura M DeGraff, Kenneth B Tomer, H Michael Jones, Liza Makowski, Leaf Huang, Samuel M Poloyac, Darryl C Zeldin, Craig R Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4195706?pdf=render

Internet

http://europepmc.org/articles/PMC4195706?pdf=render

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