An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis

An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis

Abstract Cholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol homeostasis and they supply cholesterol to the needs of neurons. ATP-binding cassette transporter A1 (ABCA1) is the...

Full description

Bibliographic Details
Main Authors: Karo Talvio, Victoria A. Wagner, Rimante Minkeviciene, Jay S. Kirkwood, Anna O. Kulinich, Juzoh Umemori, Anil Bhatia, Manhoi Hur, Reijo Käkelä, Iryna M. Ethell, Maija L. Castrén
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05147-9

Internet

https://doi.org/10.1038/s42003-023-05147-9

Similar Items