Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression

Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression

BackgroundIntracytoplasmic inclusions comprised of aggregated alpha-synuclein (αsyn) represent a key histopathological feature of neurological disorders collectively termed “synucleinopathies,” which includes Parkinson’s disease (PD). Mutations and multiplications in the SNCA gene encoding αsyn caus...

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Bibliographic Details
Main Authors: Sara J. Fagen, Jeremy D. Burgess, Melina J. Lim, Danilyn Amerna, Zeynep B. Kaya, Ayman H. Faroqi, Priyanka Perisetla, Natasha N. DeMeo, Iva Stojkovska, Drew J. Quiriconi, Joseph R. Mazzulli, Marion Delenclos, Suelen L. Boschen, Pamela J. McLean
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
alpha-synuclein (αSyn)
Parkinson’s disease
SNCA
natural compound
polyphenol
therapeutic target
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1179086/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1179086/full

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