Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy.

Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy.

R-spondin1 (Rspo1) is a member of a secreted protein family which has pleiotropic functions in development and stem cell growth. Rspo1 knock-out mice are sex-reversed, but some remain sub-fertile, so they fail to nurse their pups. A lack of Rspo1 expression in the mammary gland results in an absence...

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Bibliographic Details
Main Authors: Sead Chadi, Jacqueline Polyte, Lucas Lefevre, Johan Castille, Aude Ehanno, Johann Laubier, Florence Jaffrézic, Fabienne Le Provost
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5017653?pdf=render

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http://europepmc.org/articles/PMC5017653?pdf=render

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